When it comes to treating toenail fungus (onychomycosis), you have two main options: FDA-cleared laser therapy or prescription oral antifungal medications. Both aim to eradicate the fungus, but they differ markedly in efficacy, safety, duration, and patient experience. On this page, we break down the key differences so you can make an informed choice about the best path to clear, healthy nails.
Laser Therapy
Destroys fungal cells directly within the nail bed using targeted light energy
Clinical studies show 70–90% clearance in mild-to-moderate cases when full protocols are followed
Effective regardless of liver function or drug interactions
Oral Medications
Systemic drugs (e.g., terbinafine, itraconazole) that work via bloodstream
Reported 50–70% cure rates after 12 weeks, but relapse rates up to 20–30% within one year
Dependent on patient compliance and liver metabolism
Pain-free with no systemic exposure
Minimal side effects—rare, temporary redness or warmth
Safe for diabetics and elderly patients
Potential for liver toxicity, requiring baseline and follow-up blood tests
Common side effects: gastrointestinal upset, headache, rash
Multiple drug interactions—may be contraindicated if you take other medications
3–4 sessions of 15–30 minutes each, spaced 3–6 weeks apart
No downtime—you can resume activities immediately
Daily pills for 6–12 weeks
No downtime, but strict adherence is crucial
Nail regrowth & visible results take 3–6 months
Laser offers predictable package pricing with no hidden lab fees; oral meds can incur extra costs for blood tests and follow-up visits.
In-office treatments with immediate return to daily life
No monitoring required between sessions
High satisfaction due to minimal side effects
Self-administered at home
Requires regular lab monitoring & prescription refills
Risk of missed doses reduces effectiveness
Choose Laser Therapy If:
You want a drug-free, pain-free, and low-risk solution with high clearance rates and no need for lab monitoring.
Choose Oral Medications If:
You prefer a self-administered approach and are comfortable with blood tests and potential side effects in exchange for possible insurance coverage.
Whatever you decide, our Hicksville clinic is here to guide you.
Call 516-806-2200 or Book Your Consultation to discuss which treatment aligns best with your health needs and lifestyle.
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